since October 1, 2002


 
 
 
 
  
 
 

Standard Operating Procedures
 
Requirement
     For consistency of these operating procedures and laboratory's CHP, must prepare these parts :
          Writing basic safety rules.
          Writing general SOPs
          Writing lab-specific SOPs
          Posting poster to describe MSDS finding procedure or place.
     Officer, who involve in equipment and hazardous substance must know, understand and follow safety operating in laboratory. So develop and have Standard Operating Procedures (SOPs) documents that is laboratory technical rules and necessary for safety. SOPs have 3 parts :
          Basic Safety Rule
          General SOPs
          Lab-specific SOPs
Basic Safety Rule
     Basic safety in laboratory or proper operating procedure when work with hazardous chemical such as wearing eye protecting equipment/mask, turning off evacuating machine when finish, no smoking or eating near hazardous chemical. If officers work as operating rule, still have a problem when work with some hazardous chemical and don't know chemical operating procedure so must follow safety procedure.
General SOPs
     Mostly general SOPs are adapted from many laboratories SOPs including operating procedures that is general rule or recommendation of university and specific operating procedures for some equipment or chemical. General SOPs sources are from reference books, chemical company's documents and training equipment company such as Video Tape.
     Energy Environment Safety and Health (EESH) KMUTT recommend following general SOPs that can be adapted to keeping, using and managing chemical waste that is danger for health and environment. Laboratory officer must follow SOPs strictly. General SOPs consist of :
          1. Chemical Labels
     You must read hazardous chemical label carefully before use them every time. You must label description, condensation and danger of chemical dissolution that are prepared.
          2. Material Safety Data Sheets (MSDS)
     Every chemical user must know dangerous caution that is chemical specific property. MSDS have chemical property. Hazardous chemical is recorded in laboratory's CHP notebook. KMUTT database and EESH web site have MSDS. MSDS should be in laboratory's CHP reference file and poster display finding MSDS procedure and place obviously in each laboratory to follow Federal Hazard Communication Standard. EESH have these posters.
          3. Personal Protective Equipment (PPE)
     Personal Protective Equipment of each chemical is mentioned in caution label or MSDS such as neoprene gloves, aprons, protective glasses, etc. to use them when working with that chemical. Personal Protective Equipment rules are set up by each laboratory head who must consider hazard of chemical first. Each laboratory should have Personal Protective Equipment list what it is for and where it is. Also have cleaning, keeping and maintaining recommendation handbook.
     Personal Protective Equipment consists of eyes, hands and feet protective equipment. If you don't have enough MSDS or PPE, can contact EESH to help technically and see PPE Guideline. You can see more information from EESH web site.
          4. Container
     Recommendation on chemical container's label or from MSDS is rule for keeping and using chemical strictly.
          5. Chemical Waste
     Chemical waste must treat as local environmental regulation and KMUTT's laboratory chemical waste management rule. That rule is analyzing waste type and recording waste quantity everyday before are contained in waste container with label. Then treat some waste as description in KMUTT laboratory waste management handbook. You must follow it strictly and don't pour chemical waste in water draining pipe.
Lab - Specific SOPs
     Every laboratory or laboratory group have equipment, procedure or some chemical that have specific danger and don't have rule in general SOPs. Each laboratory head manage them properly and document their specific SOPs. Specific SOPs copy must be recorded in laboratory CHP Notebook.
     These matter of considerations help documenting Lab - specific SOPs
     1. Consider the chemical process
     Consider reaction, side effect by listing these reaction before work
     Consider intermediate and product in flammability, toxicity and reactivity by consider these :
          Can digest, how long it takes, and what is the product.
          How is stability when leave in heat, light, water, metal and etc.
          Fast attack or not.
          Can gather with other substance or not and what is reaction.
          Toxicity or not. If it is toxicity (respiration system, digest food system, irritating to the skin), what is protective procedure.
          First aid recommendation when have an accident.
     Must know such as using and maintaining equipment training, using hazardous chemical and using correct equipment.
     Finding quantity and heat and gas circulate ratio that may be left when reacting by using kinetic information and thermodynamic from reaction.
     2. Question the process dynamic
     Effect that occur.
     What are the consequences of accelerator and subsidence?
     How does air affect to the reaction?
     How to use or eradicate waste product.
     3. Develop contingency plan
     Electric current object.
     Cold system fails.
     Evacuate exhaust gas system fails.
     Higher pressure system.
     Water is leaked to system.
     Air is leaked to system.
     Burning because of reaction (have an extinguish fire equipment or not)
     Reacting containers or equipment are broken or chemical is spilled when reacting.
     4. During the process
          4.1 Prepare freezer, ventilating system, pressure lowering and air filtering
          4.2 Distinguish reacting container and check equipment that use when reacting.
          4.3 Label caution near dangerous equipment.
          4.4 Give information to companions who work in the area that have chemical and danger.
          4.5 Stay in the area and control system that make you know abnormal or dangerous situation.
          4.6 Report abnormal situation and accident immediately.
          4.7 Some laboratory equipment is specific danger. So you must document SOPs of that equipment as same as document SOPs of other specific equipment for safety user.
     5. Special Hazard and Procedure
     Each laboratory head should separate and list specific dangerous equipment, also document specific equipment or chemical using manual for special management. OSHA's laboratory standard suggest to list toxicity and procedure of specific dangerous chemical or equipment that including reproductive toxins, extreme dangerous toxins and Select Carcinogen in CHP Notebook. OSHA's laboratory standard should consider :
          1. Have place for keeping, working and using.
          2. Have proper equipment or containers when working example evacuating machine, glove box.
          3. Safety hazardous waste moving procedure.
          4. Contamination separating procedure
     Should consider working state, danger to skin, danger to breathing, personal protective equipment, air circulate system, alarm, contamination controlling system example glove boxes, contamination separating procedure and waste management. You should consult experts about these and summarize procedure before working.
     OSHA's laboratory standard set up laboratory that using hazardous chemical to follow regulation for special safety of laboratory officer. Laboratory must have special procedure and equipment to protect danger before working.
     Don't have exactly rules to give meaning or point some chemical to be hazardous chemical. Chemical has these properties must be specific control and have specific procedure :
          Toxic chemical when eating, skin touching, breathing as OSHA's dangerous substance standard.
          One of these chemicals :
               Select Carcinogen is set up by OSHA.
               National Toxicology Program (NTP) list is carcinogenic.
               National Toxicology Program (NTP) list may be carcinogenic.
               Carcinogen group in International Agency for Research on Cancer (IARC).
               Carcinogen group 2A or 2B in IARC list.
               Any chemical may cause toxicity as Safe Drinking Water and Toxic Enforcement Act of 1986.
               Another toxic chemical in laboratory.
               A mixture except have toxicity less than 1% of weight and may cause carcinogen and danger less than 0.1% of weight that don't specify laboratory officer's risk.
     Chemical Hygiene Office (CHO) director must response to set up specific hazardous chemical. After set up, must have procedure, training and efficiency equipment to get rid of danger. These procedure and training should set up area, container when working example evacuating machine, glove box, safety equipment moving procedure, separate contamination or common commitment of specific procedure before working.